Publications
Scientific papers, posters & more
Latest posters
Production of a single batch of 15 billion hiPS cells within a 10L bioreactor with an exponential amplification factor of 276-fold in 6.59 Days.
Up to 151 Millionfold Cumulated Expansion of Encapsulated hIPS Cells in Bioreactor Over 28 Days: Comparison with 2D Culture and Standard Spheroid Culture
Robust & scalable process enables the transplantation of hPSC-derived functional microtissues composed of dopaminergic neurons with best-in-class results in preclinical model of Parkinson’s disease
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Founding publications
- Philippe J.R. Cohen, Elisa Luquet, Justine Pletenka, Andrea Leonard, Elise Warter, Basile Gurchenkov, Jessica Carrere, Clément Rieu, Jerome Hardouin, Fabien Moncaubeig, Michael Lanero, Eddy Quelennec, Helene Wurtz, Emilie Jamet, Maelle Demarco, Celine Banal, Paul Van Liedekerke, Pierre Nassoy, Maxime Feyeux, Nathalie Lefort, Kevin Alessandri, Engineering 3D micro-compartments for highly efficient and scale-independent expansion of human pluripotent stem cells in bioreactors, Biomaterials, 2023, Volume 295,2023, https://doi.org/10.1016/j.biomaterials.2023.122033
- Trushko A, Di Meglio I, Merzouki A, Blanch-Mercader C, Abuhattum S, Guck J, Alessandri K, Nassoy P, Kruse K, Chopard B, Roux A. Buckling of an Epithelium Growing under Spherical Confinement. Dev Cell. 2020 Sep 14;54(5):655-668.e6. doi: 10.1016/j.devcel.2020.07.019. Epub 2020 Aug 14. PMID: 32800097; PMCID: PMC7497624.
- Le Maout V, Alessandri K, Gurchenkov B, Bertin H, Nassoy P, Sciumè G. Role of mechanical cues and hypoxia on the growth of tumor cells in strong and weak confinement: A dual in vitro-in silico approach. Sci Adv. 2020 Mar 25;6(13):eaaz7130. doi: 10.1126/sciadv.aaz7130. PMID: 32232163; PMCID: PMC7096162.
- Miguel L, Rovelet-Lecrux A, Feyeux M, Frebourg T, Nassoy P, Campion D, Lecourtois M. Detection of all adult Tau isoforms in a 3D culture model of iPSC-derived neurons. Stem Cell Res. 2019 Oct;40:101541. doi: 10.1016/j.scr.2019.101541. Epub 2019 Aug 23. PMID: 31522011.
- Andrique L, Recher G, Alessandri K, Pujol N, Feyeux M, Bon P, Cognet L, Nassoy P, Bikfalvi A. A model of guided cell self-organization for rapid and spontaneous formation of functional vessels. Sci Adv. 2019 Jun 12;5(6):eaau6562. doi: 10.1126/sciadv.aau6562. PMID: 31206014; PMCID: PMC6561743.
- Van Liedekerke P, Neitsch J, Johann T, Alessandri K, Nassoy P, Drasdo D. Quantitative cell-based model predicts mechanical stress response of growing tumor spheroids over various growth conditions and cell lines. PLoS Comput Biol. 2019 Mar 8;15(3):e1006273. doi: 10.1371/journal.pcbi.1006273. PMID: 30849070; PMCID: PMC6538187.
- Ruiz-Herrero T, Alessandri K, Gurchenkov BV, Nassoy P, Mahadevan L. Organ size control via hydraulically gated oscillations. Development. 2017 Dec 1;144(23):4422-4427. doi: 10.1242/dev.153056. PMID: 29183945.
- Doméjean H, de la Motte Saint Pierre M, Funfak A, Atrux-Tallau N, Alessandri K, Nassoy P, Bibette J, Bremond N. Controlled production of sub-millimeter liquid core hydrogel capsules for parallelized 3D cell culture. Lab Chip. 2016 Dec 20;17(1):110-119. doi: 10.1039/c6lc00848h. PMID: 27869911.
- Alessandri K, Feyeux M, Gurchenkov B, Delgado C, Trushko A, Krause KH, Vignjević D, Nassoy P, Roux A. A 3D printed microfluidic device for production of functionalized hydrogel microcapsules for culture and differentiation of human Neuronal Stem Cells (hNSC). Lab Chip. 2016 Apr 26;16(9):1593-604. doi: 10.1039/c6lc00133e. PMID: 27025278.
- Drouet V, Ruiz M, Zala D, Feyeux M, Auregan G, Cambon K, Troquier L, Carpentier J, Aubert S, Merienne N, Bourgois-Rocha F, Hassig R, Rey M, Dufour N, Saudou F, Perrier AL, Hantraye P, Déglon N. Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells. PLoS One. 2014 Jun 13;9(6):e99341. doi:10.1371/journal.pone.0099341. PMID: 24926995; PMCID: PMC4057216.
- Xu R, Feyeux M, Julien S, Nemes C, Albrechtsen M, Dinnyés A, Krause KH. Screening of bioactive peptides using an embryonic stem cell-based neurodifferentiation assay. AAPS J. 2014 May;16(3):400-12. doi: 10.1208/s12248-014-9578-7. Epub 2014 Feb 21. PMID: 24557747; PMCID: PMC4012039.
- Alessandri K, Sarangi BR, Gurchenkov VV, Sinha B, Kießling TR, Fetler L, Rico F, Scheuring S, Lamaze C, Simon A, Geraldo S, Vignjevic D, Doméjean H, Rolland L, Funfak A, Bibette J, Bremond N, Nassoy P. Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14843-8. doi: 10.1073/pnas.1309482110. Epub 2013 Aug 26. PMID: 23980147; PMCID: PMC3773746.
- Charbord J, Poydenot P, Bonnefond C, Feyeux M, Casagrande F, Brinon B, Francelle L, Aurégan G, Guillermier M, Cailleret M, Viegas P, Nicoleau C, Martinat C, Brouillet E, Cattaneo E, Peschanski M, Lechuga M, Perrier AL. High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes. Stem Cells. 2013 Sep;31(9):1816-28. doi: 10.1002/stem.1430. PMID: 23712629.
- Feyeux M, Bourgois-Rocha F, Redfern A, Giles P, Lefort N, Aubert S, Bonnefond C, Bugi A, Ruiz M, Deglon N, Jones L, Peschanski M, Allen ND, Perrier AL. Early transcriptional changes linked to naturally occurring Huntington’s disease mutations in neural derivatives of human embryonic stem cells. Hum Mol Genet. 2012 Sep 1;21(17):3883-95. doi: 10.1093/hmg/dds216. Epub 2012 Jun 7. PMID: 22678061.
- Lefort N, Feyeux M, Bas C, Féraud O, Bennaceur-Griscelli A, Tachdjian G, Peschanski M, Perrier AL. Human embryonic stem cells reveal recurrent genomic instability at 20q11.21. Nat Biotechnol. 2008 Dec;26(12):1364-6. doi: 10.1038/nbt.1509. Epub 2008 Nov 23. PMID: 19029913.