gmp device

New GMP cell encapsulation device : interview of COO Michael Lanero Fidalgo


“This GMP encapsulation device is our ticket to the clinic” Michael Lanero Fidalgo, Chief Operating Officer at TreeFrog Therapeutics, comes back on the newly delivered GMP-grade C-Stem™ platform (read full Press Release here).

Key features :

– High-throughput cell encapsulation : >1,000 capsules per second (capsules are engineered to provide cells with a biomimetic microenvironment protected from external stress).

– Suited to seed bioreactors from 200mL to 10L for :
#1 Large-scale stem cell expansion (>250x/week iPSC amplification with best-in-class cell quality)
#2 Stem cell differentiation into ready-to-graft 3D microtissues

– Easy capsule dissolution in minutes to release cellular content

Next steps:

– 2023 : transfer to CDMO to manufacture clinical-grade batches of TreeFrog’s cell therapy program in Parkinson’s disease

– 2023: 3 additional GMP encapsulation devices delivered to support TreeFrog’s cell therapy pipeline in regenerative medicine and immune-oncology

– 2024 : IND followed by first-in-human trials in Parkinson’s disease

Congrats to the froggies and our partners in automation, Invetech.