Entitled “Engineering 3D micro-compartments for highly efficient and scale-independent expansion of human pluripotent stem cells in bioreactors” this paper highlights: Biomimetic features of C-Stem™-generated capsules, allowing for in vivo-like hiPSC
We patiently compiled a comprehensive list of interventional clinical trials based on human pluripotent stem cells (both ES and iPS cells). You can sort this list by organ, indication, date,
Induced hPSCs are often touted as an infinite source of cells for research, disease modelling, and therapeutic applications. Being adherent cells, hPSCs have originally been cultured as 2D colonies in
Following a recent peer-reviewed publication describing the use of C-Stem™ for massive stem cell expansion, Maxime Feyeux, PhD, co-founder and Chief Scientific Officer of TreeFrog Therapeutics, highlights the bottlenecks that
Following a recent peer-reviewed publication describing the use of C-Stem™ for massive stem cell expansion, Maxime Feyeux, PhD, co-founder and Chief Scientific Officer of TreeFrog Therapeutics, highlights how this platform
Following a recent peer-reviewed publication describing massive hiPSC expansion in 10L bioreactors with the C-Stem™ technology, Maxime Feyeux, PhD, co-founder and Chief Scientific Officer of TreeFrog Therapeutics, provides insights into
Following a recent peer-reviewed publication describing C-Stem™ – a high-throughput cell encapsulation technology allowing for the massive expansion of pluripotent stem cells in stirred-tank bioreactors, Maxime Feyeux, PhD, co-founder and
Following a recent peer-reviewed publication describing the expansion of an iPS cell line in C-Stem™ while maintaining the same genomic profile, Maxime Feyeux, PhD, co-founder and Chief Scientific Officer of
Following a recent peer-reviewed publication describing a 275-fold amplification of human induced pluripotent stem cells (hiPSC) in a 10L bioreactors in 6.59 days with the C-Stem™ technology, Maxime Feyeux, PhD,
The lumenized rosette conformation is critical to the behavior of hPSCs in vivo. Replicating this architecture seems a logical approach to achieve in vivo-like exponential growth while preserving cell quality.
Over the past decade, developmental biology entered a golden era, fueled by novel biomimetic approaches to culture human pluripotent stem cells (hPSCs). In vitro recapitulation of the lumenized rosette conformation
The lumenized rosette architecture emerges during the transition from naïve to primed pluripotency. In response to extracellular matrix cues, naïve PSCs start to polarize. As transcriptional factors trigger primed pluripotency,
The webcast In the Stem Cell Jungle becomes a blog about pluripotent stem cells and their applications in cell therapy. Maxime Feyeux, CSO of TreeFrog, who was hosting the webcast on youtube, is now editor of the blog, which brings together developmental biology insights about pluripotent stem cells (both iPS & ES cells) and views from the industry about iPS-derived cell therapies for regenerative medicine and immune-oncology. The blog is also featuring free access resources, such as a whitebook about the epiblast rosette and how to leverage this in vivo structure to manufacture iPSCs at scale using biomimetic technologies such as C-Stem, as well as a list of cell therapy programs based on pluripotent stem cells in clinical trial.