{"id":6174,"date":"2023-03-07T08:35:47","date_gmt":"2023-03-07T08:35:47","guid":{"rendered":"https:\/\/preprod.treefrog.fr\/?p=6174"},"modified":"2023-03-07T09:23:12","modified_gmt":"2023-03-07T09:23:12","slug":"exponential-hipsc-expansion-in-10l-bioreactor-with-c-stem-published-in-biomaterials","status":"publish","type":"post","link":"https:\/\/preprod.treefrog.fr\/exponential-hipsc-expansion-in-10l-bioreactor-with-c-stem-published-in-biomaterials\/","title":{"rendered":"Exponential hiPSC expansion in 10L bioreactors with C-Stem\u2122 published in Biomaterials"},"content":{"rendered":"\t\t
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This new paper dedicated to hiPSC expansion with the C-Stem\u2122 technology platform<\/a> shows that:<\/p>\n

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  1. hiPSCs seeded in C-Stem\u2122-generated capsules self-organize into in vivo-like 3D lumenized colonies (morphologically reminiscent of epiblasts).\n<\/strong><\/strong>

    <\/strong><\/strong><\/p><\/li>\n

  2. Unprecedented >275-fold amplification of hiPSCs within 6.5 days in 10L bioreactors, with high reproducibility and maintenance of cell quality\n<\/strong><\/strong>

    <\/strong><\/strong><\/p><\/li>\n

  3. C-Stem\u2122 maintains the pluripotency and genomic integrity of hiPSCs throughout exponential expansion.<\/strong><\/li>\n<\/ol>\n

    Overall, this publication opens new perspectives for the mass production of high-quality hiPSC-derived cell therapy products.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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    \n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tAccess Publication in Biomaterials<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    We asked our co-founder and Chief Scientific Officer, Maxime Feyeux, to answer a series of frequently asked questions:\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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    How does C-Stem\u2122 achieve almost 300-fold hiPSC expansion within a week?<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    Encapsulating pluripotent stem cells: why ?<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    Why does C-Stem\u2122 preserve genomic integrity?<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    Is it possible to differentiate hiPSCs into any cell type in C-Stem\u2122?<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    What does the C-Stem\u2122 platform bring to the cell therapy field?<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    What are the limitations of the C-Stem\u2122 platform?<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    <\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    This new paper dedicated to hiPSC expansion with the C-Stem\u2122 technology platform shows that: hiPSCs seeded in C-Stem\u2122-generated capsules self-organize into in vivo-like 3D lumenized colonies (morphologically reminiscent of epiblasts). Unprecedented >275-fold amplification of hiPSCs within 6.5 days in 10L bioreactors, with high reproducibility and…<\/p>\n","protected":false},"author":1,"featured_media":6175,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12,15],"tags":[],"aioseo_notices":[],"yoast_head":"\nExponential hiPSC expansion in 10L bioreactors with C-Stem\u2122 published in Biomaterials - TreeFrog Therapeutics I iPS-derived cell therapies<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exponential hiPSC expansion in 10L bioreactors with C-Stem\u2122 published in Biomaterials - TreeFrog Therapeutics I iPS-derived cell therapies\" \/>\n<meta property=\"og:description\" content=\"This new paper dedicated to hiPSC expansion with the C-Stem\u2122 technology platform shows that: hiPSCs seeded in C-Stem\u2122-generated capsules self-organize into in vivo-like 3D lumenized colonies (morphologically reminiscent of epiblasts). Unprecedented >275-fold amplification of hiPSCs within 6.5 days in 10L bioreactors, with high reproducibility and...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/preprod.treefrog.fr\/exponential-hipsc-expansion-in-10l-bioreactor-with-c-stem-published-in-biomaterials\/\" \/>\n<meta property=\"og:site_name\" content=\"TreeFrog Therapeutics I iPS-derived cell therapies\" \/>\n<meta property=\"article:published_time\" content=\"2023-03-07T08:35:47+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-07T09:23:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/preprod.treefrog.fr\/wp-content\/uploads\/2023\/03\/Biomaterials-paper-Engineering-3D-micro-compartments-for-highly-efficient-and-scale-independent-expansion-human-pluripotent-stem-cells-in-bioreactors.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"768\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Piergueritona\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/preprod.treefrog.fr\/exponential-hipsc-expansion-in-10l-bioreactor-with-c-stem-published-in-biomaterials\/\",\"url\":\"https:\/\/preprod.treefrog.fr\/exponential-hipsc-expansion-in-10l-bioreactor-with-c-stem-published-in-biomaterials\/\",\"name\":\"Exponential hiPSC expansion in 10L bioreactors with C-Stem\u2122 published in Biomaterials - TreeFrog Therapeutics I iPS-derived cell therapies\",\"isPartOf\":{\"@id\":\"https:\/\/preprod.treefrog.fr\/#website\"},\"datePublished\":\"2023-03-07T08:35:47+00:00\",\"dateModified\":\"2023-03-07T09:23:12+00:00\",\"author\":{\"@id\":\"https:\/\/preprod.treefrog.fr\/#\/schema\/person\/ab868aec652cf07c221b48c1dc91a220\"},\"breadcrumb\":{\"@id\":\"https:\/\/preprod.treefrog.fr\/exponential-hipsc-expansion-in-10l-bioreactor-with-c-stem-published-in-biomaterials\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/preprod.treefrog.fr\/exponential-hipsc-expansion-in-10l-bioreactor-with-c-stem-published-in-biomaterials\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/preprod.treefrog.fr\/exponential-hipsc-expansion-in-10l-bioreactor-with-c-stem-published-in-biomaterials\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/preprod.treefrog.fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Exponential hiPSC expansion in 10L bioreactors with C-Stem\u2122 published in Biomaterials\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/preprod.treefrog.fr\/#website\",\"url\":\"https:\/\/preprod.treefrog.fr\/\",\"name\":\"TreeFrog Therapeutics I iPS-derived cell therapies\",\"description\":\"Cell Therapy for All\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/preprod.treefrog.fr\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/preprod.treefrog.fr\/#\/schema\/person\/ab868aec652cf07c221b48c1dc91a220\",\"name\":\"Piergueritona\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/preprod.treefrog.fr\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/5270054e7ba7a649b1bc59c924e224e1?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/5270054e7ba7a649b1bc59c924e224e1?s=96&d=mm&r=g\",\"caption\":\"Piergueritona\"},\"sameAs\":[\"https:\/\/preprod.treefrog.fr\"],\"url\":\"https:\/\/preprod.treefrog.fr\/author\/piergueritona\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Exponential hiPSC expansion in 10L bioreactors with C-Stem\u2122 published in Biomaterials - TreeFrog Therapeutics I iPS-derived cell therapies","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"Exponential hiPSC expansion in 10L bioreactors with C-Stem\u2122 published in Biomaterials - TreeFrog Therapeutics I iPS-derived cell therapies","og_description":"This new paper dedicated to hiPSC expansion with the C-Stem\u2122 technology platform shows that: hiPSCs seeded in C-Stem\u2122-generated capsules self-organize into in vivo-like 3D lumenized colonies (morphologically reminiscent of epiblasts). 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