{"id":5232,"date":"2022-10-11T10:24:11","date_gmt":"2022-10-11T10:24:11","guid":{"rendered":"https:\/\/preprod.treefrog.fr\/?p=5232"},"modified":"2022-10-11T12:10:02","modified_gmt":"2022-10-11T12:10:02","slug":"treefrog-therapeutics-moves-to-gmp-manufacturing-with-cell-encapsulation-device-delivered-by-invetech","status":"publish","type":"post","link":"https:\/\/preprod.treefrog.fr\/treefrog-therapeutics-moves-to-gmp-manufacturing-with-cell-encapsulation-device-delivered-by-invetech\/","title":{"rendered":"TreeFrog Therapeutics moves to GMP manufacturing with cell encapsulation device delivered by Invetech"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5232\" class=\"elementor elementor-5232\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1c579f7 elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"1c579f7\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0ce5e85\" data-id=\"0ce5e85\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-016b20c elementor-widget elementor-widget-text-editor\" data-id=\"016b20c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Bordeaux, France \/\u00a0October 11th, 2022<\/strong>\u00a0\u2013\u00a0<a href=\"https:\/\/preprod.treefrog.fr\/\">TreeFrog Therapeutics<\/a>,\u00a0a biotechnology company developing stem cell-derived therapies in regenerative medicine and immuno-oncology based on the biomimetic C-Stem\u2122 technology platform, and <a href=\"https:\/\/www.invetechgroup.com\/\">Invetech<\/a>, a global leader in the development and production of\u00a0automated manufacturing solutions\u00a0for cell and advanced therapies, today announced the delivery of a GMP-grade cell encapsulation device using the C-Stem\u2122 technology. The machine will be transferred in 2023 to a contract development and manufacturing organization (CDMO) to produce TreeFrog\u2019s cell therapy candidate for Parkinson\u2019s disease, with the aim of a first-in-human trial in 2024. Over 2023, Invetech will deliver three additional GMP encapsulation devices to support TreeFrog\u2019s in-house and partnered cell therapy programs in regenerative medicine and immuno-oncology.<\/p><p>Blending microfluidics and stem cell biology, TreeFrog\u2019s C-Stem\u2122 technology generates alginate capsules seeded with induced pluripotent stem cells (iPSCs) at very high speed. Engineered to mimic the <i>in vivo<\/i> stem cell niche, the capsules allow iPSCs to grow exponentially in 3D, and to differentiate into ready-to-transplant functional microtissues. And because alginate is both porous and highly resistant, encapsulated iPSCs can be expanded and differentiated in large-scale bioreactors without suffering from impeller-induced shear stress.<\/p><p><em>\u201cTreeFrog Therapeutics introduces a breakthrough technology for cell therapy, which impacts scale, quality, as well as the efficacy and safety potential of cellular products. Automating this disruptive technology and turning it into a robust GMP-grade instrument is a tremendous achievement for our team. This deliverable is the result of a very fruitful and demanding collaboration with TreeFrog\u2019s engineers in biophysics and bioproduction over the past four years. We\u2019re now eager to learn how the neural microtissues produced with C-Stem\u2122 will perform in the clinic.<\/em>\u201d <br \/>Anthony Annibale, Global VP Commercial at Invetech.<\/p><p>Started in 2019, the collaboration between TreeFrog and Invetech led to the delivery of a <a href=\"https:\/\/preprod.treefrog.fr\/treefrog-therapeutics-and-invetech-expand-partnership-to-transition-high-throughput-stem-cell-encapsulation-technology-to-gmp-system-for-commercial-scale-cell-therapy-manufacturing\/\">prototype in October 2020<\/a>. With this research-grade machine, TreeFrog demonstrated the scalability of C-Stem\u2122, moving within six months from milliliter-scale to 10-liter bioreactors. In June 2021, the company announced the production of <a href=\"https:\/\/preprod.treefrog.fr\/leap-forward-cell-therapy-manufacturing-highly-reproducible-stem-cell-expansion-10l-bioreactors-with-exponential-growth-preserved-quality\/\">two single-batches of 15 billion iPSCs in 10L bioreactors with an unprecedented 275-fold amplification per week, striking reproducibility and best-in-class cell quality<\/a>. The new GMP-grade device delivered by Invetech features the same technical specifications. The machine generates over 1,000 capsules per second, allowing to seed bioreactors from 200mL to 10L. However, the device was entirely redesigned to fit bioproduction standards.<\/p><p><em>\u201cWith the GMP device, our main challenge was to minimize the learning curve for operators, so as to facilitate tech transfer. Invetech and our team did an outstanding job in terms of automation and industrial design to make the device both robust and easy to use. As an inventor, I am so proud of the journey of the C-Stem\u2122 technology. Many elements have been changed and improved on the way, and now comes the time to put the platform in the hands of real-world users to make real products.\u201d<\/em> <br \/>Kevin Alessandri, Ph.D., Co-founder, Chief Technology Officer and Vice-President USA, TreeFrog Therapeutics<\/p><p><em>\u201cIn October 2020, we announced that we were planning for the delivery of a GMP encapsulation device by the end of 2022. Exactly two years after, we\u2019re right on time. I guess this machine testifies to the outstanding execution capacity of TreeFrog and Invetech. But more importantly, this machine constitutes a key milestone. Our platform can now be used to manufacture clinical-grade cell therapy products. Our plan is to accelerate the translation of our in-house and partnered programs to the clinic, with a focus on immuno-oncology and regenerative medicine applications.\u201d<\/em> <br \/>Frederic Desdouits, Ph.D., Chief Executive Officer, TreeFrog Therapeutics<\/p><p><strong>About Invetech<\/strong><\/p><p>For pathfinders in cell and gene therapy striving to accelerate next-generation care, Invetech delivers robust, scalable and cost-effective\u00a0<a href=\"https:\/\/www.invetechgroup.com\/cell-therapy-formulation-fill\/\">manufacturing systems<\/a>\u00a0for clinical through to high-volume commercial production. Since 2003, Invetech\u2019s Cell Therapy Group has provided Assured Pathways\u2122 to the commercial manufacturing of cell, gene and tissue therapies, including peripheral and precursor materials such as viral vector and media. Invetech configures manufacturing systems to address client process demands, building from portfolio of proven modules and platform technology. Invetech is a globally recognized leader in life science automation, and a member of the Fortive (NYSE: FTV) group of companies.\u00a0<br \/><a href=\"https:\/\/www.invetechgroup.com\/\">invetechgroup.com<\/a><\/p><p><strong>About TreeFrog Therapeutics<\/strong><\/p><p>TreeFrog Therapeutics is a French-based biotech company aiming to unlock access to cell therapies for millions of patients. Bringing together over 100 biophysicists, cell biologists and bioproduction engineers, TreeFrog Therapeutics raised $82M over the past 3 years to advance a pipeline of stem cell-based therapies in immuno-oncology and regenerative medicine. In 2022, the company opened technological hubs in Boston, USA, and Kobe, Japan, with the aim of driving the adoption of the C-Stem\u2122 platform and establish strategic alliances with leading academic, biotech and industry players in the field of cell therapy.<\/p><p><a href=\"https:\/\/preprod.treefrog.fr\/\">www.treefrog.fr<\/a><\/p><p><strong>Media Contact<\/strong><\/p><p>Pierre-Emmanuel Gaultier<br \/>TreeFrog Therapeutics<br \/>+ 33 6 45 77 42 58\u00a0<br \/><a href=\"mailto:pierre@treefrog.fr\">pierre@treefrog.fr<\/a><\/p><p><a href=\"https:\/\/preprod.treefrog.fr\/wp-content\/uploads\/2022\/10\/GMP-Encapsulation-Device-TreeFrog-Therapeutics-iPS-cell-therapies-c-stem-f-scaled.jpg\">Download full resolution picture<\/a> (credits: TreeFrog Therapeutics)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>The machine will be transferred in 2023 to a contract development and manufacturing organization (CDMO) to produce TreeFrog\u2019s cell therapy candidate for Parkinson\u2019s disease, with the aim of a first-in-human trial in 2024. Over 2023, Invetech will deliver three additional GMP encapsulation devices to support TreeFrog\u2019s in-house and partnered cell therapy programs in regenerative medicine and immuno-oncology.<\/p>\n","protected":false},"author":1,"featured_media":5233,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[12,13,1],"tags":[],"aioseo_notices":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>TreeFrog Therapeutics moves to GMP manufacturing with cell encapsulation device delivered by Invetech - TreeFrog Therapeutics I iPS-derived cell therapies<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"TreeFrog Therapeutics moves to GMP manufacturing with cell encapsulation device delivered by Invetech - TreeFrog Therapeutics I iPS-derived cell therapies\" \/>\n<meta property=\"og:description\" content=\"The machine will be transferred in 2023 to a contract development and manufacturing organization (CDMO) to produce TreeFrog\u2019s cell therapy candidate for Parkinson\u2019s disease, with the aim of a first-in-human trial in 2024. 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