{"id":2568,"date":"2023-03-07T09:23:19","date_gmt":"2023-03-07T09:23:19","guid":{"rendered":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/?p=2568"},"modified":"2023-03-07T09:34:10","modified_gmt":"2023-03-07T09:34:10","slug":"why-does-c-stem-preserve-genomic-integrity","status":"publish","type":"post","link":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/why-does-c-stem-preserve-genomic-integrity\/","title":{"rendered":"Why does C-Stem\u2122 preserve genomic integrity?"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2568\" class=\"elementor elementor-2568\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9497965 elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"9497965\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-53f4d8f\" data-id=\"53f4d8f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f8124ab elementor-widget elementor-widget-text-editor\" data-id=\"f8124ab\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Following a recent peer-reviewed publication describing the expansion of an iPS cell line in C-Stem\u2122 while maintaining the same genomic profile, Maxime Feyeux, PhD, co-founder and Chief Scientific Officer of TreeFrog Therapeutics, explains how such maintenance of genomic integrity is possible in C-Stem\u2122.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d52e70 elementor-widget elementor-widget-video\" data-id=\"0d52e70\" data-element_type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/912ueSTqnJU&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-62d0912 elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"62d0912\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-40bd1e5\" data-id=\"40bd1e5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d155f1e elementor-widget elementor-widget-text-editor\" data-id=\"d155f1e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><b>Transcript:<\/b><\/p><p>\u00a0<\/p><p>One other question that we have is: Why do we have claims on genomic integrity maintenance ? We have an insight as to the impact of the culture system on genomic integrity. That&#8217;s a bold claim. So basically we checked the genome of the cells going in the C-Stem\u2122, and the genome of the cells after amplification &#8211; going out of C-Stem\u2122. And basically we have a match. So we maintain the genomic integrity. That&#8217;s something that we should have: in vivo, the pluripotent stem cells they ought to maintain the genomic integrity, because if there is a problem, then the whole body is going to inherit it. So there&#8217;s a huge pressure to do a good job there. And basically in classical culture systems you actually see mutations accruing over time. So that&#8217;s a very important thing to check for. And I would say that the usual suspect as to why we have that drift is that there is a lot of cell death. And if you have a mutation that gives you a survival advantage, you&#8217;re going to be selected for, especially if there is a lot of cell death. If you don&#8217;t have much cell death, you&#8217;re not\u00a0going to have the opportunity to be selected for.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-04e2a5c elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"04e2a5c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8ae3fd2\" data-id=\"8ae3fd2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-09536d0 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"09536d0\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/doi.org\/10.1016\/j.biomaterials.2023.122033\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">READ THE PAPER<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Following a recent peer-reviewed publication describing the expansion of an iPS cell line in C-Stem\u2122 while maintaining the same genomic profile, Maxime Feyeux, PhD, co-founder and Chief Scientific Officer of TreeFrog Therapeutics, explains how such maintenance of genomic integrity is possible in C-Stem\u2122.<\/p>\n","protected":false},"author":1,"featured_media":2570,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"video","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[],"aioseo_notices":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Why does C-Stem\u2122 preserve genomic integrity? 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