{"id":2506,"date":"2021-01-20T15:13:00","date_gmt":"2021-01-20T15:13:00","guid":{"rendered":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/?p=2506"},"modified":"2023-03-03T15:18:42","modified_gmt":"2023-03-03T15:18:42","slug":"transplanting-pancreatic-progenitors-vs-mature-%ce%b2-cell","status":"publish","type":"post","link":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/transplanting-pancreatic-progenitors-vs-mature-%ce%b2-cell\/","title":{"rendered":"Transplanting Pancreatic Progenitors Vs Mature \u03b2-Cells"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2506\" class=\"elementor elementor-2506\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2126bb99 elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"2126bb99\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3cf2a611\" data-id=\"3cf2a611\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27737069 elementor-widget elementor-widget-text-editor\" data-id=\"27737069\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tAlbert Hwa, Operations Director at the Joslin&#8217;s Center for Cell-Based Therapy for Diabetes (CCTD) and Lecturer the Harvard Medical School, gives a quick overview of the limitations of pancreatic progenitor transplants.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-12442ae elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"12442ae\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ae8a13c\" data-id=\"ae8a13c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ff0861f elementor-widget elementor-widget-video\" data-id=\"ff0861f\" data-element_type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/8Tzczoo0D1o&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ccdeaee elementor-widget elementor-widget-text-editor\" data-id=\"ccdeaee\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Transcript:<\/strong><\/p><p>\u00a0<\/p><p>And then coming back to this notion of [\u03b2-cell] maturity, and also the timing relative to to graft, it feels to me like for quite a while, there&#8217;s been cells that, if they were grafted would mature in situ and have an effect. And now here comes the time when you don&#8217;t rely that much on the capacity of the body to push the maturation.<\/p><p>\u00a0<\/p><p>And you have a better control with these protocols over the cell type and its function, early on after graft. That would be the the biggest difference.<\/p><p>\u00a0<\/p><p>Yeah, and I think it has sort of&#8230; both on a safety front and a functional front, I think both are really important because there were some reports where the way you transplant the earlier stage progenitors&#8230; They, in addition, to the endocrine cells, they also made some non-endocrine cells. So then that could have some safety concerns. So then, if you can differentiate all the way to the more mature endocrine cell type you have greater control over that. And I think that has probably better safety profile and functionally &#8211; obviously if I was a patient &#8211; I don&#8217;t want to have a transplant I have to wait many more months before the function kicks in. You want it to work as soon as possible.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-85e4be2 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"85e4be2\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"http:\/\/And%20then%20coming%20back%20to%20this%20notion%20of%20[\u03b2-cell]%20maturity,%20and%20also%20the%20timing%20relative%20to%20to%20graft,%20it%20feels%20to%20me%20like%20for%20quite%20a%20while,%20there&#039;s%20been%20cells%20that,%20if%20they%20were%20grafted%20would%20mature%20in%20situ%20and%20have%20an%20effect.%20And%20now%20here%20comes%20the%20time%20when%20you%20don&#039;t%20rely%20that%20much%20on%20the%20capacity%20of%20the%20body%20to%20push%20the%20maturation.%20%20And%20you%20have%20a%20better%20control%20with%20these%20protocols%20over%20the%20cell%20type%20and%20its%20function,%20early%20on%20after%20graft.%20That%20would%20be%20the%20the%20biggest%20difference.%20%20Yeah,%20and%20I%20think%20it%20has%20sort%20of...%20both%20on%20a%20safety%20front%20and%20a%20functional%20front,%20%20I%20think%20both%20are%20really%20important%20because%20there%20were%20some%20reports%20where%20the%20way%20you%20transplant%20the%20earlier%20stage%20progenitors...%20They,%20in%20addition,%20to%20the%20endocrine%20cells,%20they%20also%20made%20some%20non-endocrine%20cells.%20So%20then%20that%20could%20have%20some%20safety%20concerns.%20So%20then,%20if%20you%20can%20differentiate%20all%20the%20way%20to%20the%20more%20mature%20endocrine%20cell%20type%20you%20have%20greater%20control%20over%20that.%20And%20I%20think%20that%20has%20probably%20better%20safety%20profile%20and%20functionally%20-%20obviously%20if%20I%20was%20a%20patient%20-%20I%20don&#039;t%20want%20to%20have%20a%20transplant%20I%20have%20to%20wait%20many%20more%20months%20before%20the%20function%20kicks%20in.%20You%20want%20it%20to%20work%20as%20soon%20as%20possible.\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Watch full video<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Albert Hwa, Operations Director at the Joslin&#8217;s Center for Cell-Based Therapy for Diabetes (CCTD) and Lecturer the Harvard Medical School, gives a quick overview of the limitations of pancreatic progenitor transplants.<\/p>\n","protected":false},"author":1,"featured_media":2507,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[],"aioseo_notices":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Transplanting Pancreatic Progenitors Vs Mature \u03b2-Cells - Stem Cells &amp; 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