{"id":2487,"date":"2021-01-20T14:57:00","date_gmt":"2021-01-20T14:57:00","guid":{"rendered":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/?p=2487"},"modified":"2023-03-03T15:03:24","modified_gmt":"2023-03-03T15:03:24","slug":"cell-therapy-for-diabetes-immune-tolerance-vs-shielded-strategies","status":"publish","type":"post","link":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/cell-therapy-for-diabetes-immune-tolerance-vs-shielded-strategies\/","title":{"rendered":"Cell Therapy for Diabetes : immune tolerance vs shielded strategies"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2487\" class=\"elementor elementor-2487\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2cb363f4 elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"2cb363f4\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-79116321\" data-id=\"79116321\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1cc49daa elementor-widget elementor-widget-text-editor\" data-id=\"1cc49daa\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tAlbert Hwa, Operations Director at the Joslin&#8217;s Center for Cell-Based Therapy for Diabetes (CCTD) and Lecturer the Harvard Medical School, discusses the pro and cons of shielding stem-cell derived \u03b2-Cells with alginate, versus strategies aiming at reducing the immunogenicity of transplanted cells.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ad80c5f elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"ad80c5f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d451cd5\" data-id=\"d451cd5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-11f91d3 elementor-widget elementor-widget-video\" data-id=\"11f91d3\" data-element_type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/NDbsU8I5JHM&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7505788 elementor-widget elementor-widget-text-editor\" data-id=\"7505788\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>I think eventually the field is going to move quite towards immune tolerance, whether it&#8217;s some kind of strategy to directly tolarize the host, or you can modify your stem cell product to remove some of the immunogenicity. <\/p><p>And then the reason I say that is&#8230; I think it&#8217;s definitely a very attractive idea to encapsulate the cells to block the immune response against the cells. But then you create these other problems like slowing the kinetics, and then some kind of oxygen limitation, you know if the oxygen can&#8217;t come in as fast then you cannot put as many cells in these devices. And so it&#8217;s a trade-off between these kind of safety concerns and that. I think a lot of the companies, they all want to address the safety, so they can go into the clinic a little faster. I think in the beginning you saw most companies say their main program is encapsulation, but then you now see that ViaCyte is working with CRISPR Therapeutics.<\/p><p>And so I would imagine that if they&#8217;re modifying the the cells for their immunogenicity, then I think the point will be not to encapsulate\u00a0them.<\/p><p>Similarly I think Semma, which is now part of Vertex, I think they have also publicly said that they also have a non-encapsulation program. So I think they understand that biologically it makes more sense to have direct vascularization of the cells. I think it&#8217;s better for the long term durability of your cell graft and also better for their function. So I think eventually we will probably go the route of non-encapsulation.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-114a322 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"114a322\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/youtu.be\/xQ22EZivLBk\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Watch full video<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Albert Hwa, Operations Director at the Joslin&#8217;s Center for Cell-Based Therapy for Diabetes (CCTD) and Lecturer the Harvard Medical School, discusses the pro and cons of shielding stem-cell derived \u03b2-Cells with alginate, versus strategies aiming at reducing the immunogenicity of transplanted cells. <\/p>\n","protected":false},"author":1,"featured_media":2495,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[],"aioseo_notices":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cell Therapy for Diabetes : immune tolerance vs shielded strategies - Stem Cells &amp; 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