{"id":2352,"date":"2022-03-24T10:20:13","date_gmt":"2022-03-24T10:20:13","guid":{"rendered":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/?p=2352"},"modified":"2023-02-14T10:22:43","modified_gmt":"2023-02-14T10:22:43","slug":"enhancing-car-t-cell-activity-with-tissue-resident-immune-cells-miriam-merad-stem-cell-jungle","status":"publish","type":"post","link":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/enhancing-car-t-cell-activity-with-tissue-resident-immune-cells-miriam-merad-stem-cell-jungle\/","title":{"rendered":"Enhancing CAR-T cell activity with tissue resident immune cells | Miriam Merad | Stem Cell Jungle"},"content":{"rendered":"\t\t
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Miriam Merad, MD, PhD, Oncologist and Director of the Precision Immunology Institute at Mount Sinai in New-York is an expert of tissue-resident immune cells in cancer. Here she highlights the rationale behind strategies targeting macrophages and dendritic cells with the aim of enhancing CAR-T and NK cells anti-tumor activity.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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So CAR-Ts: you generate T cells that can recognize a tumor antigen. This is generated ex vivo. The T cells have been manipulated usually to recognize a [tumor antigen] through genetic manipulation. This is what we call a CAR. So, you introduce a CAR that allows the T cells to recognize, and when they recognize the tumor antigen they should kill. So you can hypothesize that they will not need any type of help, because those T cells are going to go directly to the tumor lesions, and then recognize the target and then kill the target. Now we realize that as soon as the T cells arrive in any type of tissue microenvironment, they’re going to be influenced by the cells\u00a0that are in that microenvironment.<\/p>

So there is a lot of interest, including in my laboratory, to use the microenvironment to further enhance CAR-T cells function. CAR-T cells work, but not 100% of the cases.<\/p>

There has been dramatic successes, but there has been also a lot of failures, especially in solid tumors. And the focus now is to understand how we can really manipulate tissue-resident dendritic cells and macrophages, to enhance CAR-T cell function, and many of us are looking into this. There’s a big project that I’m doing in collaboration with several CAR-T cell groups looking at this specific question. It is a very valid hypothesis to think that these tissue-resident immune cells can have a tremendous impact on CAR-T cells and NKs. Because their role is to bring these T-cells\u00a0in. And they have a privileged way of interacting with\u00a0those T-cells so we should be able to harness them.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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