{"id":2286,"date":"2022-02-14T09:50:56","date_gmt":"2022-02-14T09:50:56","guid":{"rendered":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/?p=2286"},"modified":"2023-02-14T09:54:31","modified_gmt":"2023-02-14T09:54:31","slug":"cell-therapies-in-immuno-oncology-from-academia-to-big-pharma-neil-sheppard-stem-cell-jungle","status":"publish","type":"post","link":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/cell-therapies-in-immuno-oncology-from-academia-to-big-pharma-neil-sheppard-stem-cell-jungle\/","title":{"rendered":"Cell therapies in Immuno-Oncology : from Academia to Big Pharma | Neil Sheppard | Stem Cell Jungle"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2286\" class=\"elementor elementor-2286\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9497965 elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"9497965\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-53f4d8f\" data-id=\"53f4d8f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f8124ab elementor-widget elementor-widget-text-editor\" data-id=\"f8124ab\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>With a 20-year experience in cancer immunotherapies, Neil Sheppard, comes back on the early days of CAR-T cell therapies, talking about Novartis, U. Penn, Juno, Kite&#8230;<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d52e70 elementor-widget elementor-widget-video\" data-id=\"0d52e70\" data-element_type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/x47gu244oWQ&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-62d0912 elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"62d0912\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-40bd1e5\" data-id=\"40bd1e5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d155f1e elementor-widget elementor-widget-text-editor\" data-id=\"d155f1e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><b>Transcript:<\/b><\/p>\n<p>\u00a0<\/p>\n<p>The cell therapy field has been around for a\u00a0long time but it was purely of academic interest.<\/p>\n<p>So the whole TIL process is kind of horrendously complicated. You need to take surgically excised tumor tissue and digest it etc. So it&#8217;s very difficult. But really so big pharma hasn&#8217;t really been interested in cell therapy until much more recently. So, my current boss, Carl June, he published in 2012 &#8211; so 10 years ago &#8211; some really stunning responses in patients with leukemia and lymphoma treated with the CD19 CAR therapy. And that kind of surprisingly and amazingly Novartis, the big drug company Novartis, engaged with that\u00a0right away. So, that&#8217;s when big pharma really started taking notice. Although I think it&#8217;s\u00a0also fair to say that they were an outlier. So the other big pharma companies didn&#8217;t jump in at\u00a0that time. The kind of CAR-19 race was between Novartis with U.Penn. And also players like Kite\u00a0and Juno, which were biotech companies of course.<\/p>\n<p>Biotech companies take up generally quite a lot more risk than big pharma companies. And it wasn&#8217;t until years later that they were acquired by various big pharma and bigger biotech companies. And so, the cell therapy field is really kind of moving into the big pharma.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-04e2a5c elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"04e2a5c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8ae3fd2\" data-id=\"8ae3fd2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-09536d0 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"09536d0\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/youtu.be\/Ed33lE_b5Pw\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">WATCH FULL VIDEO<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>With a 20-year experience in cancer immunotherapies, Neil Sheppard, comes back on the early days of CAR-T cell therapies, talking about Novartis, U. 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