{"id":2222,"date":"2022-09-21T09:28:52","date_gmt":"2022-09-21T09:28:52","guid":{"rendered":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/?p=2222"},"modified":"2023-02-14T09:40:37","modified_gmt":"2023-02-14T09:40:37","slug":"ipsc-derived-nk-cells-versus-t-cells-differentiation-amplification-in-vivo-function-neil-sheppard-stem-cell-jungle","status":"publish","type":"post","link":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/ipsc-derived-nk-cells-versus-t-cells-differentiation-amplification-in-vivo-function-neil-sheppard-stem-cell-jungle\/","title":{"rendered":"iPSC-derived NK cells versus T cells : differentiation, amplification, in vivo function | Neil Sheppard | Stem Cell Jungle"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2222\" class=\"elementor elementor-2222\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9497965 elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"9497965\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-53f4d8f\" data-id=\"53f4d8f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f8124ab elementor-widget elementor-widget-text-editor\" data-id=\"f8124ab\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Neil Sheppard, D.Phil, Adjunct Associate Professor in the Department of Pathology &amp; Laboratory Medicine, and Head of the T Cell Engineering Lab (TCEL), at the Center for Cellular Immunotherapies (CCI) at the University of Pennsylvania has a 20-year experience in the field of immunotherapies and vaccines. In this interview, he highlights the difference cell sources available to make allogeneic NK and T cells, the related manufacturing challenges, as well recent clinical results with such products.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d52e70 elementor-widget elementor-widget-video\" data-id=\"0d52e70\" data-element_type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/VGrjIZ-IDIk&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-62d0912 elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"62d0912\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-40bd1e5\" data-id=\"40bd1e5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d155f1e elementor-widget elementor-widget-text-editor\" data-id=\"d155f1e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Transcript:<br \/><br \/><\/b><\/p><p>Some companies are blazing a trial using healthy adult donors, some are using cord blood derived NK-cells, some use the stem cells from the cord blood to make NK-cells. And then the ones that use iPSC technology to make NK-cells. It definitely seems much easier to get an authentic NK cell out of an iPSC, than an authentic T cell. I say easy, it&#8217;s clearly not easy. I think companies have spent more than a decade perfecting it but comparatively, you&#8217;re more likely to get a good NK than a good T cell out of an iPSC. And you know you can grow these cells for a long time, that&#8217;s one of the downsides of T cells is that it&#8217;s very conclusively shown that the more you grow them the more they exhaust. And this is why the Novartis is planning to move from nine days to two days and why data from the paper on the one day\u00a0process looks better than the nine day process.<\/p><p>The less you do to the T cells outside the body,\u00a0the better they are. With NK cells it doesn&#8217;t seem to be the case. And many of these\u00a0companies grow NK cells from healthy donors and cord blood etc for two or three weeks, to get\u00a0really large numbers. You can potentially grow them at a bioreactor scale, maybe in the future. And iPSCs of course give you like the ability to make massive numbers of NK cells to then\u00a0use. I see them repeatedly giving good data in hematological malignancies. So unmodified NK-cells\u00a0of the right phenotype they&#8217;re kind of adaptive or memory-like phenotypes seem to be very potent\u00a0in AML. And I think that will be one of the places they get approved. The CD19 CAR-NK look really\u00a0promising. The only thing I would caution is that a lot of the trials we&#8217;ve seen are only very\u00a0small in scale. Some of them use fresh NK cells because NK cells are difficult to cryopreserve. So that needs fixing. And the doses used can be quite large. So some of these companies\u00a0reporting recently are using doses of a billion cells per infusion and they&#8217;re giving three\u00a0infusions per cycle and they&#8217;re giving two infusion cycles so then that&#8217;s six billion cells\u00a0per patient. That makes me wonder how&#8230; I&#8217;m not quite sure I believe them yet if they say they can make\u00a0a production run does a thousand patients. I don&#8217;t think that they really say that until they&#8217;ve\u00a0worked out how many NK cells each patient needs.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-04e2a5c elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"04e2a5c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8ae3fd2\" data-id=\"8ae3fd2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-09536d0 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"09536d0\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/youtu.be\/Ed33lE_b5Pw\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">WATCH FULL VIDEO<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Neil Sheppard, D.Phil, Adjunct Associate Professor in the Department of Pathology &#038; Laboratory Medicine,  and Head of the T Cell Engineering Lab (TCEL), at the Center for Cellular Immunotherapies (CCI) at the University of Pennsylvania has a 20-year experience in the field of immunotherapies and vaccines. In this interview, he highlights the difference cell sources available to make allogeneic NK and T cells, the related manufacturing challenges, as well recent clinical results with such products.<\/p>\n","protected":false},"author":1,"featured_media":2265,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"video","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[],"aioseo_notices":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>iPSC-derived NK cells versus T cells : differentiation, amplification, in vivo function | Neil Sheppard | Stem Cell Jungle - Stem Cells &amp; Cell Therapy Blog I In the Stem Cell Jungle I iPSCs I TreeFrog Therapeutics<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"iPSC-derived NK cells versus T cells : differentiation, amplification, in vivo function | Neil Sheppard | Stem Cell Jungle - Stem Cells &amp; Cell Therapy Blog I In the Stem Cell Jungle I iPSCs I TreeFrog Therapeutics\" \/>\n<meta property=\"og:description\" content=\"Neil Sheppard, D.Phil, Adjunct Associate Professor in the Department of Pathology &amp; Laboratory Medicine, and Head of the T Cell Engineering Lab (TCEL), at the Center for Cellular Immunotherapies (CCI) at the University of Pennsylvania has a 20-year experience in the field of immunotherapies and vaccines. 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