{"id":2054,"date":"2023-02-09T14:54:44","date_gmt":"2023-02-09T14:54:44","guid":{"rendered":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/?p=2054"},"modified":"2023-03-07T09:58:55","modified_gmt":"2023-03-07T09:58:55","slug":"release-of-the-white-paper-on-the-hipsc-lumenized-rosette","status":"publish","type":"post","link":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/release-of-the-white-paper-on-the-hipsc-lumenized-rosette\/","title":{"rendered":"Release of the White Paper on the hiPSC lumenized rosette"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2054\" class=\"elementor elementor-2054\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f572bd4 elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"f572bd4\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-12c628c\" data-id=\"12c628c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c31aba6 elementor-widget elementor-widget-text-editor\" data-id=\"c31aba6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The discovery by Shinya Yamanaka in 2006 of key transcription factors enabling the reprogrammation of somatic cells to the pluripotent state triggered massive access to human pluripotent stem cells (hPSCs).<\/p><p>Induced hPSCs are often touted as an infinite source of cells for research, disease modelling, and therapeutic applications. Being adherent cells, hPSCs have originally been cultured as 2D colonies in Petri dishes or T-flasks. However, despite their apparent unlimited proliferation capacity, hPSCs only exist for a few days <em>in vivo<\/em> and do not grow as 2D colonies. <em>In vivo<\/em>, pluripotency (here restricted to human primed pluripotency) is only observed during the second week of human development, and exclusively within 3D epithelialized arrangements of cells.<\/p><p>To overcome the intrinsic limitations of 2D cell culture systems with respect to hPSC expansion \u2013 especially high mortality and genomic alterations \u2013, novel cell culture technologies that mimic the hPSC niche have recently been developed, bringing a new breath to academic research and industrial applications.<\/p><h3>\u00a0<\/h3><h3>This white paper aims at:<\/h3><p>\u00a0<\/p><ul><li style=\"list-style-type: none;\"><ul><li>Describing the <em>in vivo<\/em> environment of hPSCs, with a focus on the lumenized rosette conformation<\/li><\/ul><\/li><\/ul><p>\u00a0<\/p><ul><li style=\"list-style-type: none;\"><ul><li>Comparing the <em>in vivo<\/em> organization of hPSCs to standard in vitro cell culture systems<\/li><\/ul><\/li><\/ul><p>\u00a0<\/p><ul><li style=\"list-style-type: none;\"><ul><li>Reviewing biomimetic systems that scientists can implement in their lab to culture hPSCs in lumenized rosette conformation<\/li><\/ul><\/li><\/ul><p>\u00a0<\/p><ul><li>Introducing <a href=\"https:\/\/preprod.treefrog.fr\/c-stem-technology-scaling-up-ips-derived-cell-therapy-manufacturing-bioreactors\/\">C-Stem\u2122<\/a> \u2013 a biomimetic technology allowing for the mass-production and differentiation of hPSCs in large-scale bioreactors<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b1cfbad elementor-widget elementor-widget-shortcode\" data-id=\"b1cfbad\" data-element_type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\"><div 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class=\"tve_shortcode_editor\"><div class=\"thrv-leads-form-box tve_no_drag tve_no_icons thrv_wrapper tve_editor_main_content thrv-leads-in-content tve_empty_dropzone\" data-css=\"tve-u-18636d86ba7\" style=\"\"><div class=\"thrv_wrapper tve_image_caption tve_ea_tl_state_lightbox\" data-css=\"tve-u-18636d86ba8\" style=\"\"><span class=\"tve_image_frame\"><img loading=\"lazy\" decoding=\"async\" class=\"tve_image wp-image-1351 tve_evt_manager_listen tve_et_click\" alt=\"White Paper hiPSC mimicking the lumenized rosette epiblast pluripotent stem cells in vivo\" data-id=\"1351\" width=\"576\" data-init-width=\"2500\" height=\"1600\" data-init-height=\"1600\" title=\"whitebook epiblast\" loading=\"lazy\" src=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/01\/Horizontal_Book_Mockup_Whitebook.jpg\" data-width=\"576\" data-css=\"tve-u-18636da3ba6\" style=\"\" data-tcb-events=\"__TCB_EVENT_[{&quot;config&quot;:{&quot;anim&quot;:&quot;instant&quot;,&quot;s&quot;:&quot;25&quot;},&quot;a&quot;:&quot;tl_state_lightbox&quot;,&quot;t&quot;:&quot;click&quot;}]_TNEVE_BCT__\"><\/span><\/div><div class=\"thrv_wrapper thrv_contentbox_shortcode thrv-content-box tve_evt_manager_listen tve_et_click tve_ea_tl_state_lightbox\" data-css=\"tve-u-18636d86baa\" style=\"--tve-cond-height-m:158; --tve-cond-height-d:68.3594;\" data-tcb-events=\"__TCB_EVENT_[{&quot;config&quot;:{&quot;anim&quot;:&quot;instant&quot;,&quot;s&quot;:&quot;25&quot;},&quot;a&quot;:&quot;tl_state_lightbox&quot;,&quot;t&quot;:&quot;click&quot;}]_TNEVE_BCT__\"><div class=\"tve-content-box-background\" data-css=\"tve-u-18636d86bac\" data-tcb_hover_state_parent=\"1\" style=\"\"><\/div><div class=\"tve-cb\" data-css=\"tve-u-18636d86bad\" style=\"\"><div class=\"thrv_wrapper thrv-columns\" data-css=\"tve-u-18636d86bae\" style=\"--tcb-col-el-width:581;\"><div class=\"tcb-flex-row tcb--cols--1\" data-css=\"tve-u-18636d86baf\" style=\"\"><div class=\"tcb-flex-col\" data-css=\"tve-u-18636d86bb0\" style=\"\"><div class=\"tcb-col\" data-css=\"tve-u-18636d86bb1\" style=\"\"><div class=\"thrv_wrapper thrv_text_element tve_ea_tl_state_lightbox\" data-css=\"tve-u-18636d86bb2\"><p data-css=\"tve-u-18636d86bb3\" style=\"text-align: center;\"><a class=\"tve_evt_manager_listen tve_et_click\" data-css=\"tve-u-18636d86bb5\" data-tcb-events=\"__TCB_EVENT_[{&quot;a&quot;:&quot;tl_state_lightbox&quot;,&quot;t&quot;:&quot;click&quot;,&quot;config&quot;:{&quot;s&quot;:&quot;25&quot;,&quot;anim&quot;:&quot;instant&quot;}}]_TNEVE_BCT__\" href=\"javascript:void(0)\" target=\"_blank\" style=\"outline: none;\"><span data-css=\"tve-u-18636d86bb6\"><span style=\"text-decoration: underline;\">Download<\/span> White Paper on the hPSC Lumenized Rosette<\/span><\/a><\/p><p><\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Induced hPSCs are often touted as an infinite source of cells for research, disease modelling, and therapeutic applications. Being adherent cells, hPSCs have originally been cultured as 2D colonies in Petri dishes or T-flasks. However, despite their apparent unlimited proliferation capacity, hPSCs only exist for a few days in vivo and do not grow as 2D colonies. In vivo, pluripotency (here restricted to human primed pluripotency) is only observed during the second week of human development, and exclusively within 3D epithelialized arrangements of cells.<\/p>\n","protected":false},"author":1,"featured_media":1351,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[9,3],"tags":[],"aioseo_notices":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Release of the White Paper on the hiPSC lumenized rosette - Stem Cells &amp; Cell Therapy Blog I In the Stem Cell Jungle I iPSCs I TreeFrog Therapeutics<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Release of the White Paper on the hiPSC lumenized rosette - Stem Cells &amp; Cell Therapy Blog I In the Stem Cell Jungle I iPSCs I TreeFrog Therapeutics\" \/>\n<meta property=\"og:description\" content=\"Induced hPSCs are often touted as an infinite source of cells for research, disease modelling, and therapeutic applications. 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In vivo, pluripotency (here restricted to human primed pluripotency) is only observed during the second week of human development, and exclusively within 3D epithelialized arrangements of cells.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/release-of-the-white-paper-on-the-hipsc-lumenized-rosette\/\" \/>\n<meta property=\"og:site_name\" content=\"Stem Cells &amp; Cell Therapy Blog I In the Stem Cell Jungle I iPSCs I TreeFrog Therapeutics\" \/>\n<meta property=\"article:published_time\" content=\"2023-02-09T14:54:44+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-07T09:58:55+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/01\/Horizontal_Book_Mockup_Whitebook.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2500\" \/>\n\t<meta property=\"og:image:height\" content=\"1600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Piergueritona\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@treefrogtx\" \/>\n<meta name=\"twitter:site\" content=\"@treefrogtx\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/release-of-the-white-paper-on-the-hipsc-lumenized-rosette\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/release-of-the-white-paper-on-the-hipsc-lumenized-rosette\/\"},\"author\":{\"name\":\"Piergueritona\",\"@id\":\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/#\/schema\/person\/ab868aec652cf07c221b48c1dc91a220\"},\"headline\":\"Release of the White Paper on the hiPSC lumenized rosette\",\"datePublished\":\"2023-02-09T14:54:44+00:00\",\"dateModified\":\"2023-03-07T09:58:55+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/release-of-the-white-paper-on-the-hipsc-lumenized-rosette\/\"},\"wordCount\":240,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/#organization\"},\"articleSection\":[\"Articles\",\"Freebies\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/release-of-the-white-paper-on-the-hipsc-lumenized-rosette\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/release-of-the-white-paper-on-the-hipsc-lumenized-rosette\/\",\"url\":\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/release-of-the-white-paper-on-the-hipsc-lumenized-rosette\/\",\"name\":\"Release of the White Paper on the hiPSC lumenized rosette - Stem Cells &amp; 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Being adherent cells, hPSCs have originally been cultured as 2D colonies in Petri dishes or T-flasks. However, despite their apparent unlimited proliferation capacity, hPSCs only exist for a few days in vivo and do not grow as 2D colonies. 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