{"id":1290,"date":"2020-11-05T11:52:00","date_gmt":"2020-11-05T11:52:00","guid":{"rendered":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/?p=1290"},"modified":"2023-02-14T09:34:28","modified_gmt":"2023-02-14T09:34:28","slug":"ips-cell-safety-the-oncopanel-test-i-laurence-daheron-i-in-the-stem-cell-jungle","status":"publish","type":"post","link":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/ips-cell-safety-the-oncopanel-test-i-laurence-daheron-i-in-the-stem-cell-jungle\/","title":{"rendered":"iPS cell safety : the Oncopanel Test I Laurence Daheron I In the Stem Cell Jungle"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1290\" class=\"elementor elementor-1290\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9497965 elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"9497965\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-53f4d8f\" data-id=\"53f4d8f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f8124ab elementor-widget elementor-widget-text-editor\" data-id=\"f8124ab\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Laurence Daheron, Phd, Head of the iPS Core Facility at the Harvard Stem Cell Institute, discusses the industrial challenges related to cell therapies: manufacturing, safety testing, administration mode.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d52e70 elementor-widget elementor-widget-video\" data-id=\"0d52e70\" data-element_type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/E0I3J2yWkRc&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-62d0912 elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"62d0912\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-40bd1e5\" data-id=\"40bd1e5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d155f1e elementor-widget elementor-widget-text-editor\" data-id=\"d155f1e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Transcript: <\/b><\/p><p>\u00a0<\/p><p>We are obviously not focusing so much on cGMP or clinical grade IPS. Obviously for clinical-grade iPS, you need to say a lot more but all the different mutations that could arise during the reprogramming and the expansion. So we had one collaboration with a group at Dana Farber where we generated some cGMP lines. And what we did for this line is a test called oncopanel. And we looked at, I think it was, about 446 onco genes, looking at any CNV or SNV in this 446 onco genes. So instead of doing any Seq, or full genome sequencing, we decided to focus on just onco genes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-04e2a5c elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"04e2a5c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8ae3fd2\" data-id=\"8ae3fd2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-09536d0 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"09536d0\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/youtu.be\/M-HfMi8WyR8\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">WATCH FULL VIDEO<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Laurence Daheron, Phd, Head of the iPS Core Facility at the Harvard Stem Cell Institute, presents the Oncopanel strategy to evaluate the genomic safety of clinical-grade iPS lines.<\/p>\n","protected":false},"author":1,"featured_media":1997,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"video","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[4],"tags":[],"aioseo_notices":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>iPS cell safety : the Oncopanel Test I Laurence Daheron I In the Stem Cell Jungle - Stem Cells &amp; 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