{"id":1130,"date":"2023-01-25T13:03:42","date_gmt":"2023-01-25T13:03:42","guid":{"rendered":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/?page_id=1130"},"modified":"2023-03-07T10:01:25","modified_gmt":"2023-03-07T10:01:25","slug":"ips-derived-cell-therapy-blog-latest-articles-in-the-stem-cell-jungle-by-treefrog-therapeutics","status":"publish","type":"page","link":"https:\/\/preprod.treefrog.fr\/stemcelljungle\/ips-derived-cell-therapy-blog-latest-articles-in-the-stem-cell-jungle-by-treefrog-therapeutics\/","title":{"rendered":"Articles"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1130\" class=\"elementor elementor-1130\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d1f9dee elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"d1f9dee\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-41da5a7\" data-id=\"41da5a7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fc00b0d elementor-widget elementor-widget-image\" data-id=\"fc00b0d\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/gif-maxime.gif\" class=\"attachment-full size-full wp-image-1408\" alt=\"gif-maxime\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-4ed9efe\" data-id=\"4ed9efe\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-af6a8c3 elementor-widget elementor-widget-heading\" data-id=\"af6a8c3\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-xl\">Making your way into the wild new world of pluripotent stem cells &amp; cell therapies...<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0363ba9 elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"0363ba9\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c7d90e3\" data-id=\"c7d90e3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2cd4615 elementor-nav-menu__align-center elementor-nav-menu__text-align-center elementor-nav-menu--dropdown-tablet elementor-widget elementor-widget-nav-menu\" data-id=\"2cd4615\" data-element_type=\"widget\" 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class=\"elementor-post__thumbnail__link\" href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/new-paper-in-biomaterials-describes-massive-hipsc-expansion-in-10l-bioreactors\/\" target=\"_blank\"><div class=\"elementor-post__thumbnail\"><img width=\"1024\" height=\"768\" src=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/03\/Biomaterials-paper-Engineering-3D-micro-compartments-for-highly-efficient-and-scale-independent-expansion-human-pluripotent-stem-cells-in-bioreactors.jpg\" class=\"attachment-full size-full wp-image-2632\" alt=\"New paper in Biomaterial describes the C-Stem\u2122 platform for massive hiPSC expansion in 10L bioreactors\" decoding=\"async\" srcset=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/03\/Biomaterials-paper-Engineering-3D-micro-compartments-for-highly-efficient-and-scale-independent-expansion-human-pluripotent-stem-cells-in-bioreactors.jpg 1024w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/03\/Biomaterials-paper-Engineering-3D-micro-compartments-for-highly-efficient-and-scale-independent-expansion-human-pluripotent-stem-cells-in-bioreactors-300x225.jpg 300w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/03\/Biomaterials-paper-Engineering-3D-micro-compartments-for-highly-efficient-and-scale-independent-expansion-human-pluripotent-stem-cells-in-bioreactors-768x576.jpg 768w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/03\/Biomaterials-paper-Engineering-3D-micro-compartments-for-highly-efficient-and-scale-independent-expansion-human-pluripotent-stem-cells-in-bioreactors-800x600.jpg 800w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/03\/Biomaterials-paper-Engineering-3D-micro-compartments-for-highly-efficient-and-scale-independent-expansion-human-pluripotent-stem-cells-in-bioreactors-700x525.jpg 700w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/div><\/a>\n\t\t\t\t<div class=\"elementor-post__badge\">Articles<\/div>\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h3 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/new-paper-in-biomaterials-describes-massive-hipsc-expansion-in-10l-bioreactors\/\" target=&quot;_blank&quot;>\n\t\t\t\tNew paper in Biomaterials describes massive hiPSC expansion in 10L bioreactors\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t<div class=\"elementor-post__excerpt\">\n\t\t\t<p>Entitled \u201cEngineering 3D micro-compartments for highly efficient and scale-independent expansion of human pluripotent stem cells in bioreactors\u201d this paper highlights: Biomimetic features of C-Stem\u2122-generated capsules, allowing for in vivo-like hiPSC self-organization into lumenized rosettes \/ Unprecedented exponential hiPSC growth in 10L bioreactors: >275-fold within 6.5 days, with high reproducibility \/ Maintenance of cell quality (pluripotency &#038; genonomic integrity) throughout massive expansion <\/p>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-post__read-more-wrapper\">\n\t\t\n\t\t<a class=\"elementor-post__read-more\" href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/new-paper-in-biomaterials-describes-massive-hipsc-expansion-in-10l-bioreactors\/\" target=\"_blank\">\n\t\t\tRead More \u00bb\t\t<\/a>\n\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-post__meta-data\">\n\t\t\t\t\t<span class=\"elementor-post-date\">\n\t\t\tMarch 7, 2023\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-2054 post type-post status-publish format-standard has-post-thumbnail hentry category-articles category-freebies\">\n\t\t\t<div class=\"elementor-post__card\">\n\t\t\t\t<a class=\"elementor-post__thumbnail__link\" href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/release-of-the-white-paper-on-the-hipsc-lumenized-rosette\/\" target=\"_blank\"><div class=\"elementor-post__thumbnail\"><img width=\"2500\" height=\"1600\" src=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/01\/Horizontal_Book_Mockup_Whitebook.jpg\" class=\"attachment-full size-full wp-image-1351\" alt=\"White Paper hiPSC mimicking the lumenized rosette epiblast pluripotent stem cells in vivo\" decoding=\"async\" srcset=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/01\/Horizontal_Book_Mockup_Whitebook.jpg 2500w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/01\/Horizontal_Book_Mockup_Whitebook-300x192.jpg 300w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/01\/Horizontal_Book_Mockup_Whitebook-1024x655.jpg 1024w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/01\/Horizontal_Book_Mockup_Whitebook-768x492.jpg 768w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/01\/Horizontal_Book_Mockup_Whitebook-1536x983.jpg 1536w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/01\/Horizontal_Book_Mockup_Whitebook-2048x1311.jpg 2048w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/01\/Horizontal_Book_Mockup_Whitebook-700x448.jpg 700w\" sizes=\"(max-width: 2500px) 100vw, 2500px\" \/><\/div><\/a>\n\t\t\t\t<div class=\"elementor-post__badge\">Articles<\/div>\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h3 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/release-of-the-white-paper-on-the-hipsc-lumenized-rosette\/\" target=&quot;_blank&quot;>\n\t\t\t\tRelease of the White Paper on the hiPSC lumenized rosette\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t<div class=\"elementor-post__excerpt\">\n\t\t\t<p>Induced hPSCs are often touted as an infinite source of cells for research, disease modelling, and therapeutic applications. Being adherent cells, hPSCs have originally been cultured as 2D colonies in Petri dishes or T-flasks. However, despite their apparent unlimited proliferation capacity, hPSCs only exist for a few days in vivo and do not grow as 2D colonies. In vivo, pluripotency (here restricted to human primed pluripotency) is only observed during the second week of human development, and exclusively within 3D epithelialized arrangements of cells.<\/p>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-post__read-more-wrapper\">\n\t\t\n\t\t<a class=\"elementor-post__read-more\" href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/release-of-the-white-paper-on-the-hipsc-lumenized-rosette\/\" target=\"_blank\">\n\t\t\tRead More \u00bb\t\t<\/a>\n\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-post__meta-data\">\n\t\t\t\t\t<span class=\"elementor-post-date\">\n\t\t\tFebruary 9, 2023\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-2166 post type-post status-publish format-standard has-post-thumbnail hentry category-articles\">\n\t\t\t<div class=\"elementor-post__card\">\n\t\t\t\t<a class=\"elementor-post__thumbnail__link\" href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/c-stem-scale-up-expansion-human-pluripotent-stem-cells-bioreactors\/\" target=\"_blank\"><div class=\"elementor-post__thumbnail\"><img loading=\"lazy\" width=\"1920\" height=\"1080\" src=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/C-Stem-scale-up-human-pluripotent-stem-cells-expansion-bioreactor.jpg\" class=\"attachment-full size-full wp-image-2207\" alt=\"How does C-Stem\u2122 enable to scale-up the expansion of human pluripotent stem cells in bioreactors ?\" decoding=\"async\" srcset=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/C-Stem-scale-up-human-pluripotent-stem-cells-expansion-bioreactor.jpg 1920w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/C-Stem-scale-up-human-pluripotent-stem-cells-expansion-bioreactor-300x169.jpg 300w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/C-Stem-scale-up-human-pluripotent-stem-cells-expansion-bioreactor-1024x576.jpg 1024w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/C-Stem-scale-up-human-pluripotent-stem-cells-expansion-bioreactor-768x432.jpg 768w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/C-Stem-scale-up-human-pluripotent-stem-cells-expansion-bioreactor-1536x864.jpg 1536w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/C-Stem-scale-up-human-pluripotent-stem-cells-expansion-bioreactor-700x394.jpg 700w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/C-Stem-scale-up-human-pluripotent-stem-cells-expansion-bioreactor-539x303.jpg 539w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/><\/div><\/a>\n\t\t\t\t<div class=\"elementor-post__badge\">Articles<\/div>\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h3 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/c-stem-scale-up-expansion-human-pluripotent-stem-cells-bioreactors\/\" target=&quot;_blank&quot;>\n\t\t\t\tHow does C-Stem\u2122 enable to scale-up the expansion of human pluripotent stem cells in bioreactors ?\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t<div class=\"elementor-post__excerpt\">\n\t\t\t<p>The lumenized rosette conformation is critical to the behavior of hPSCs in vivo. Replicating this architecture seems a logical approach to achieve in vivo-like exponential growth while preserving cell quality. However, current protocols for hPSC culture in lumenized rosette conformation were not designed for scale-up. The C-Stem\u2122 platform was invented to fill this gap.<\/p>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-post__read-more-wrapper\">\n\t\t\n\t\t<a class=\"elementor-post__read-more\" href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/c-stem-scale-up-expansion-human-pluripotent-stem-cells-bioreactors\/\" target=\"_blank\">\n\t\t\tRead More \u00bb\t\t<\/a>\n\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-post__meta-data\">\n\t\t\t\t\t<span class=\"elementor-post-date\">\n\t\t\tFebruary 8, 2023\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-1002 post type-post status-publish format-standard has-post-thumbnail hentry category-articles\">\n\t\t\t<div class=\"elementor-post__card\">\n\t\t\t\t<a class=\"elementor-post__thumbnail__link\" href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/how-to-grow-hipscs-in-lumenized-rosette-conformation-in-the-lab\/\" target=\"_blank\"><div class=\"elementor-post__thumbnail\"><img loading=\"lazy\" width=\"1920\" height=\"1080\" src=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/generating-lumenized-epiblast-rosette-protocol-TreeFrog-In-The-Stem-Cell-Jungle-web.jpg\" class=\"attachment-full size-full wp-image-1840\" alt=\"generating lumenized epiblast rosette protocol TreeFrog In The Stem Cell Jungle web\" decoding=\"async\" srcset=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/generating-lumenized-epiblast-rosette-protocol-TreeFrog-In-The-Stem-Cell-Jungle-web.jpg 1920w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/generating-lumenized-epiblast-rosette-protocol-TreeFrog-In-The-Stem-Cell-Jungle-web-300x169.jpg 300w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/generating-lumenized-epiblast-rosette-protocol-TreeFrog-In-The-Stem-Cell-Jungle-web-1024x576.jpg 1024w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/generating-lumenized-epiblast-rosette-protocol-TreeFrog-In-The-Stem-Cell-Jungle-web-768x432.jpg 768w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/generating-lumenized-epiblast-rosette-protocol-TreeFrog-In-The-Stem-Cell-Jungle-web-1536x864.jpg 1536w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/generating-lumenized-epiblast-rosette-protocol-TreeFrog-In-The-Stem-Cell-Jungle-web-700x394.jpg 700w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/generating-lumenized-epiblast-rosette-protocol-TreeFrog-In-The-Stem-Cell-Jungle-web-539x303.jpg 539w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/><\/div><\/a>\n\t\t\t\t<div class=\"elementor-post__badge\">Articles<\/div>\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h3 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/how-to-grow-hipscs-in-lumenized-rosette-conformation-in-the-lab\/\" target=&quot;_blank&quot;>\n\t\t\t\tHow to grow hiPSCs in lumenized rosette conformation in the lab ?\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t<div class=\"elementor-post__excerpt\">\n\t\t\t<p>Over the past decade, developmental biology entered a golden era, fueled by novel biomimetic approaches to culture human pluripotent stem cells (hPSCs). In vitro recapitulation of the lumenized rosette conformation was described by the group of Magdalena Zernicka-Goetz in 2014 using mice PSCs cultured in micro-wells coated with Matrigel\u00ae. This approach was then successfully applied to human ES and iPS cells in 2016 by the same team.<\/p>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-post__read-more-wrapper\">\n\t\t\n\t\t<a class=\"elementor-post__read-more\" href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/how-to-grow-hipscs-in-lumenized-rosette-conformation-in-the-lab\/\" target=\"_blank\">\n\t\t\tRead More \u00bb\t\t<\/a>\n\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-post__meta-data\">\n\t\t\t\t\t<span class=\"elementor-post-date\">\n\t\t\tFebruary 7, 2023\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-2148 post type-post status-publish format-standard has-post-thumbnail hentry category-articles\">\n\t\t\t<div class=\"elementor-post__card\">\n\t\t\t\t<a class=\"elementor-post__thumbnail__link\" href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/how-do-lumenized-pluripotent-stem-cell-colonies-form-and-what-are-their-properties\/\" target=\"_blank\"><div class=\"elementor-post__thumbnail\"><img loading=\"lazy\" width=\"1920\" height=\"1080\" src=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/lumenogenesis-pluripotent-stem-cell-epiblast-rosette-TreeFrog-In-The-Stem-Cell-Jungle-web.jpg\" class=\"attachment-full size-full wp-image-1836\" alt=\"Genesis &amp; properties of the pluripotent lumenized rosette\" decoding=\"async\" srcset=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/lumenogenesis-pluripotent-stem-cell-epiblast-rosette-TreeFrog-In-The-Stem-Cell-Jungle-web.jpg 1920w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/lumenogenesis-pluripotent-stem-cell-epiblast-rosette-TreeFrog-In-The-Stem-Cell-Jungle-web-300x169.jpg 300w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/lumenogenesis-pluripotent-stem-cell-epiblast-rosette-TreeFrog-In-The-Stem-Cell-Jungle-web-1024x576.jpg 1024w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/lumenogenesis-pluripotent-stem-cell-epiblast-rosette-TreeFrog-In-The-Stem-Cell-Jungle-web-768x432.jpg 768w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/lumenogenesis-pluripotent-stem-cell-epiblast-rosette-TreeFrog-In-The-Stem-Cell-Jungle-web-1536x864.jpg 1536w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/lumenogenesis-pluripotent-stem-cell-epiblast-rosette-TreeFrog-In-The-Stem-Cell-Jungle-web-700x394.jpg 700w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/lumenogenesis-pluripotent-stem-cell-epiblast-rosette-TreeFrog-In-The-Stem-Cell-Jungle-web-539x303.jpg 539w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/><\/div><\/a>\n\t\t\t\t<div class=\"elementor-post__badge\">Articles<\/div>\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h3 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/how-do-lumenized-pluripotent-stem-cell-colonies-form-and-what-are-their-properties\/\" target=&quot;_blank&quot;>\n\t\t\t\tHow do lumenized pluripotent stem cell colonies form and what are their properties ?\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t<div class=\"elementor-post__excerpt\">\n\t\t\t<p>The lumenized rosette architecture emerges during the transition from na\u00efve to primed pluripotency. In response to extracellular matrix cues, na\u00efve PSCs start to polarize. As transcriptional factors trigger primed pluripotency, hPSC form de novo intracellular actin-rich compartments called apicosomes, which accumulate Ca2+ and express apical proteins. As apicosomes regroup, concomitant mechanisms promoting water influx towards the center of the epiblast participate in the establishment of a fluid-filled lumen. The resulting rosette architecture displays apical-basal polarity: all apical domains are facing the lumen, while basal domains are facing the external environment of the epiblast.<\/p>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-post__read-more-wrapper\">\n\t\t\n\t\t<a class=\"elementor-post__read-more\" href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/how-do-lumenized-pluripotent-stem-cell-colonies-form-and-what-are-their-properties\/\" target=\"_blank\">\n\t\t\tRead More \u00bb\t\t<\/a>\n\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-post__meta-data\">\n\t\t\t\t\t<span class=\"elementor-post-date\">\n\t\t\tFebruary 1, 2023\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-2158 post type-post status-publish format-standard has-post-thumbnail hentry category-articles\">\n\t\t\t<div class=\"elementor-post__card\">\n\t\t\t\t<a class=\"elementor-post__thumbnail__link\" href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/human-pluripotent-stem-cells-in-vitro-versus-in-vivo\/\" target=\"_blank\"><div class=\"elementor-post__thumbnail\"><img loading=\"lazy\" width=\"1920\" height=\"1080\" src=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/comparison-2D-cell-culture-aggregate-in-vivo-pluripotent-stem-cell-expansion-TreeFrog-In-The-Stem-Cell-Jungle-web-1.jpg\" class=\"attachment-full size-full wp-image-1838\" alt=\"Comparison of standard 2D culture and 3D aggregate culture to the in vivo lumenized rosette\" decoding=\"async\" srcset=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/comparison-2D-cell-culture-aggregate-in-vivo-pluripotent-stem-cell-expansion-TreeFrog-In-The-Stem-Cell-Jungle-web-1.jpg 1920w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/comparison-2D-cell-culture-aggregate-in-vivo-pluripotent-stem-cell-expansion-TreeFrog-In-The-Stem-Cell-Jungle-web-1-300x169.jpg 300w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/comparison-2D-cell-culture-aggregate-in-vivo-pluripotent-stem-cell-expansion-TreeFrog-In-The-Stem-Cell-Jungle-web-1-1024x576.jpg 1024w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/comparison-2D-cell-culture-aggregate-in-vivo-pluripotent-stem-cell-expansion-TreeFrog-In-The-Stem-Cell-Jungle-web-1-768x432.jpg 768w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/comparison-2D-cell-culture-aggregate-in-vivo-pluripotent-stem-cell-expansion-TreeFrog-In-The-Stem-Cell-Jungle-web-1-1536x864.jpg 1536w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/comparison-2D-cell-culture-aggregate-in-vivo-pluripotent-stem-cell-expansion-TreeFrog-In-The-Stem-Cell-Jungle-web-1-700x394.jpg 700w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/comparison-2D-cell-culture-aggregate-in-vivo-pluripotent-stem-cell-expansion-TreeFrog-In-The-Stem-Cell-Jungle-web-1-539x303.jpg 539w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/><\/div><\/a>\n\t\t\t\t<div class=\"elementor-post__badge\">Articles<\/div>\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h3 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/human-pluripotent-stem-cells-in-vitro-versus-in-vivo\/\" target=&quot;_blank&quot;>\n\t\t\t\tHuman pluripotent stem cells: in vitro versus in vivo\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t<div class=\"elementor-post__excerpt\">\n\t\t\t<p>While it has been reported that hPSCs cultured in 2D spontaneously form lumens, such rosette-like structures were found to rapidly collapse (in ~5 days or less). hPSCs end up establishing an inverted topology in 2D. As opposed to the rosette architecture, in Petri dishes the apical domain is facing the cell culture media, while the basal pole is established at the bottom of the dish, with limited access to external cues and nutrients. As a result, in 2D culture, signalling molecules secreted at the apical domain are diluted in a large volume of media, which is rinsed at every media change. Developmental biologist Marta Shahbazi estimated a 2,500-fold difference in the concentration of autocrine factors in the lumen of hPSC colonies in rosette conformation versus cell culture medium in standard 2D culture.<\/p>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-post__read-more-wrapper\">\n\t\t\n\t\t<a class=\"elementor-post__read-more\" href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/human-pluripotent-stem-cells-in-vitro-versus-in-vivo\/\" target=\"_blank\">\n\t\t\tRead More \u00bb\t\t<\/a>\n\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-post__meta-data\">\n\t\t\t\t\t<span class=\"elementor-post-date\">\n\t\t\tJanuary 20, 2023\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-941 post type-post status-publish format-standard has-post-thumbnail hentry category-articles\">\n\t\t\t<div class=\"elementor-post__card\">\n\t\t\t\t<a class=\"elementor-post__thumbnail__link\" href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/how-do-human-pluripotent-stem-cells-grow-in-vivo\/\" target=\"_blank\"><div class=\"elementor-post__thumbnail\"><img loading=\"lazy\" width=\"1920\" height=\"1080\" src=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/Human-primed-pluripotency-in-vivo-TreeFrog-In-The-Stem-Cell-Jungle-web.jpg\" class=\"attachment-full size-full wp-image-1833\" alt=\"Human primed pluripotency in vivo TreeFrog In The Stem Cell Jungle\" decoding=\"async\" srcset=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/Human-primed-pluripotency-in-vivo-TreeFrog-In-The-Stem-Cell-Jungle-web.jpg 1920w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/Human-primed-pluripotency-in-vivo-TreeFrog-In-The-Stem-Cell-Jungle-web-300x169.jpg 300w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/Human-primed-pluripotency-in-vivo-TreeFrog-In-The-Stem-Cell-Jungle-web-1024x576.jpg 1024w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/Human-primed-pluripotency-in-vivo-TreeFrog-In-The-Stem-Cell-Jungle-web-768x432.jpg 768w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/Human-primed-pluripotency-in-vivo-TreeFrog-In-The-Stem-Cell-Jungle-web-1536x864.jpg 1536w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/Human-primed-pluripotency-in-vivo-TreeFrog-In-The-Stem-Cell-Jungle-web-700x394.jpg 700w, https:\/\/preprod.treefrog.fr\/stemcelljungle\/wp-content\/uploads\/sites\/5\/2023\/02\/Human-primed-pluripotency-in-vivo-TreeFrog-In-The-Stem-Cell-Jungle-web-539x303.jpg 539w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/><\/div><\/a>\n\t\t\t\t<div class=\"elementor-post__badge\">Articles<\/div>\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h3 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/how-do-human-pluripotent-stem-cells-grow-in-vivo\/\" target=&quot;_blank&quot;>\n\t\t\t\tHow do human pluripotent stem cells grow in vivo ?\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t<div class=\"elementor-post__excerpt\">\n\t\t\t<p>Pluripotency is a transient cell property in vivo. At the end of the first week of development, na\u00efve hPSCs transition to primed pluripotency. Within the following 5 to 7 days, the hPSC colony, benefiting from a very fast 15h to 16h cell cycle, grows exponentially to reach over 1,000 cells. <\/p>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-post__read-more-wrapper\">\n\t\t\n\t\t<a class=\"elementor-post__read-more\" href=\"https:\/\/preprod.treefrog.fr\/stemcelljungle\/how-do-human-pluripotent-stem-cells-grow-in-vivo\/\" target=\"_blank\">\n\t\t\tRead More \u00bb\t\t<\/a>\n\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-post__meta-data\">\n\t\t\t\t\t<span class=\"elementor-post-date\">\n\t\t\tJanuary 7, 2023\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/article>\n\t\t\t\t<\/div>\n\n\n\t\t\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8383d9d elementor-section-boxed elementor-section-height-default elementor-section-height-default parallax_section_no qode_elementor_container_no\" data-id=\"8383d9d\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8dd8a87\" data-id=\"8dd8a87\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-18ae126 elementor-widget elementor-widget-text-editor\" data-id=\"18ae126\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h1><span style=\"font-size: 8.0pt; font-family: 'quicksand',sans-serif;\">iPS-derived Cell Therapy Blog: Latest articles<\/span><\/h1>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Making your way into the wild new world of pluripotent&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_theme","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"aioseo_notices":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>iPS-derived Cell Therapy Blog: Latest articles<\/title>\n<meta name=\"description\" content=\"What will you find on our new scientific blog ? 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